The centre-back has been a mainstay in the United side this term since his £80m move from Leicester City last summer and has earned praise from Solskjaer for playing through the pain barrier.
After a mixed start at Old Trafford, Maguire’s form has picked up since the New Year which has helped United to shore up their defence in recent weeks, keeping five clean sheets in the last seven matches.
But the Red Devils will have to do without their skipper against Derby and Solskjaer insists he could miss Sunday’s Manchester Derby after ‘rolling’ his ankle in training.
‘I had a word with him [Maguire] before training yesterday that I’m not going to rest him, but then he rolled his ankle in training,’ said Solskjaer.
‘He had to stay at home and hopefully he’ll be ok for the weekend but I’m not sure.
Maguire took to Twitter after the team news was announced and confirmed he is injured.
‘Disappointed to miss out through injury – working hard to get fit ASAP,’ said Maguire.
The Red Devils face rivals Manchester City at Old Trafford on Sunday and will need to be on top form if they’re take a crucial three points in their pursuit of a Champions League spot.
United take on former club captain Wayne Rooney at Pride Park after the former Everton ace’s move from MLS side DC United in January.
A win at Pride Park would set-up a quarter-final clash against Norwich City at Carrow Road after the Canaries knocked out Spurs in a penalty shootout on Wednesday.
Odion Ighalo is making just his second appearance for the club and will be looking to make it two goals in as many starts following his full debut effort against Club Brugge last Thursday.
Daniel James and Aaron Wan-Bissaka were other notable absentees from the squad but Solskjaer is confident that both will be fit on the weekend.